Unexpected photo-instability of 2,6-sulfonamide-substituted BODIPYs and its application to development of caged GABA
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چکیده
Investigation of the unexpected photo-instability of 2,6sulfonamide-substituted derivatives of the boron dipyrromethene (BODIPY) fluorophore led to discovery of a photoreaction accompanied with multiple bond scissions. We characterized the photoproducts, and utilized the photoreaction to design a caged gamma-aminobutyric acid (GABA) derivative that can release GABA upon irradiation in the visible range (> 450 nm). This allowed us to stimulate neural cells in mouse brain slices.
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تاریخ انتشار 2016